Napa Tablet
Paracetamol
500 mg
Beximco Pharmaceuticals Ltd.
Unit Price: ৳ 0.80 (100's pack: ৳ 80.04)
Unit Price: ৳ 0.80 (500's pack: ৳ 400.20)
Unit Price: ৳ 0.80 (510's pack: ৳ 408.20)
ndications
Paracetamol
is indicated for fever, common cold and influenza, headache, toothache,
earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back
pain, post-operative pain, postpartum pain, inflammatory pain and post
vaccination pain in children. It is also indicated for rheumatic &
osteoarthritic pain and stiffness of joints.
Therapeutic Class
Non opioid
analgesics
Pharmacology
Paracetamol
has analgesic and antipyretic properties with weak anti-inflammatory activity.
Paracetamol (Acetaminophen) is thought to act primarily in the CNS, increasing
the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2,
and COX-3 enzymes involved in prostaglandin (PG) synthesis.
Paracetamol is a para aminophenol derivative, has analgesic and antipyretic
properties with weak anti-inflammatory activity. Paracetamol is one of the most
widely used, safest and fast acting analgesic. It is well tolerated and free
from various side effects of aspirin.
Dosage & Administration
Tablet:
Adult: 1-2 tablets every 4 to 6 hours up to a
maximum of 4 gm (8 tablets) daily.
Children
(6-12 years): ½ to
1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed
the dose beyond 2.6 gm/day.
Extended
Release Tablet:
Adults
& Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6
tablets in any 24 hours).The tablet must not be crushed.
Syrup/Suspension:
Children
under 3 months: 10
mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
3
months to below 1 year:
½ to 1 teaspoonful 3 to 4 times daily.
1-5
years: 1 -2 teaspoonful
3 to 4 times daily.
6-12
years: 2-A teaspoonful
3 to 4 times daily.
Adults: 4-8 teaspoonful 3 to 4 times daily.
Suppository:
Children
3-12 months: 60-120
mg,4 times daily.
Children
1-5 years: 125-250 mg 4
times daily.
Children
6-12 years: 250-500 mg
4 times daily.
Adults
& children over 12 years: 0.5-1 gm 4 times daily.
Paediatric
Drop:
Children
Upto 3 months: 0.5 ml
(40 mg)
4 to 11
months: 1.0 ml (80 mg)
7 to 2
years: 1.5 ml (120 mg).
Do not exceed more than 5 dose daily for a maximum of 5 days.
Paracetamol
tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol
tablets. It is a fast acting and safe analgesic with marked antipyretic
property. It is specially suitable for patients who, for any reason, can not
tolerate aspirin or other analgesics.
Adults
and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not
take more than 8 caplets in 24 hours.
Children
(7 to 11 years): Take
½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets
in 24 hours. Not recommended in children under 7 years.
Interaction
Patients who
have taken barbiturates, tricyclic antidepressants and alcohol may show
diminished ability to metabolise large doses of Paracetamol. Alcohol can
increase the hepatotoxicity of Paracetamol overdosage. Chronic ingestion of
anticonvulsants or oral steroid contraceptives induce liver enzymes and may
prevent attainment of therapeutic Paracetamol levels by increasing first-pass
metabolism or clearance.
Contraindications
It is
contraindicated in known hypersensitivity to Paracetamol.
Side Effects
Side effects
of paracetamol are usually mild, though haematological reactions including
thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis
have been reported. Pancreatitis, skin rashes, and other allergic reactions
occur occasionally.
Pregnancy & Lactation
Pregnancy
category B according to USFDA. This drug should be used during pregnancy only
if clearly needed
Precautions & Warnings
Paracetamol
should be given with caution to patients with impaired kidney or liver
function. Paracetamol should be given with care to patients taking other drugs
that affect the liver.
Overdose Effects
Symptoms of
Paracetamol overdose in the first 24 hours are pallor, nausea, vomiting,
anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after
ingestion. Abnormalities of glucose metabolism and metabolic acidosis may
occur.
Storage Conditions
Keep in a
dry place away from light and heat. Keep out of the reach of children.