Why it's used
Tenoloc Tablet is used for the management of high blood pressure. It is a prescription medicine. This medicine works by relaxing the blood vessels and slowing down the heart rate in order to improve blood flow and to decrease the high blood pressure conditions. Tenoloc is also used for the long-term treatment of chest pain due to reduced blood flow to the heart (angina pectoris caused by coronary atherosclerosis). This medicine works by reducing the requirement of oxygen to the heart. It also helps in the reduction of heart rate and the ability of the heart muscle to contract (contractility) thereby making it effective in reducing the symptoms of chest pain. It is also used for the management of heart attack. This medicine works by increasing the requirement of oxygen to heart by increasing left ventricular fiber length and end diastolic pressure in patients who have heart failure. Tenoloc is also used for the management of increased or decreased heartbeat.
Atenolol is indicated
In the management of hypertension. It may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.
For the long-term management of patients with angina pectoris.
In the management of hemodynamically stable patients with defnite or suspected acute myocardial infarction to reduce cardiovascular mortality.
Beta-adrenoceptor blocking drugs, Beta-blockers
The synthesis of atenolol resulted from attempts to produce a β-adrenoceptor antagonist that would competitively block β1 (cardiac) receptors but have no effect on β2-receptors. It is classified as a β1 selective (cardioselective) β-adrenergic receptor antagonist with no membranestability activity and no partial agonist activity. It is markedly the most hydrophilic of the currently available β- blockers and thus penetrates the lipid of cell membranes poorly
Dosage & Administration
Hypertension: The initial dose of Atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.
Angina Pectoris: he initial dose of Atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect.
Twenty-four hour control with once daily dosing is achieved by giving doses larger than necessary to achieve an immediate maximum effect. The maximum early effect on exercise tolerance occurs with doses of 50 to 100 mg, but at these doses the effect at 24 hours is attenuated, averaging about 50% to 75% of that observed with once a day oral doses of 200 mg.